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M94A2902.TXT
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1994-10-25
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Document 2902
DOCN M94A2902
TI HIV associated dementia: frequency and differentiating factors compared
to other neurological complications of HIV infection.
DT 9412
AU Sanchez-Portocarrero J; Jimenez-Escrig A; Ayuso J; Perez-Cecilia E; Roca
V; Barquero M; Varela de Seijas E; Hospital Clinico, Madrid, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):199 (abstract no. PB0224). Unique
Identifier : AIDSLINE ICA10/94369673
AB OBJECTIVES: Define the frequency of appearance of HIV associated
dementia (HAD) and establish the differentiating factors which may exist
when it is compared to other HIV associated neurological disorders
(HAND). METHOD: During a period of four years (1989-1992) we studied
prospectively the patients presenting HAND in our hospital. RESULTS: Out
of a total of 142, 23 patients (16.2%) were diagnosed as having HAD
according to WHO criteria; this condition is the second most common
HAND, after cerebral toxoplasmosis. No statistically significant
differences sex, age, risk group, or stage of HIV infection- were
established between the HAD patients and the other HAND diagnosed in the
group. Among the HAD patients, levels of hemoglobin, hematocrit and
total lymphocytes were significantly lower, and the B2M and IgA blood
levels were higher. CD4-cell count showed no differences between the
groups. HAD was associated with a CT scan with cerebral atrophy. HAD
patients had a higher survival rate, with a bad functional situation and
a lesser frequency of deaths of neurological origin. CONCLUSION: HAD is
the second most frequent HAND. In relation to other HAND, it has a very
low mortality of neurological origin, and a very high morbidity.
DE Atrophy AIDS Dementia Complex/BLOOD/DIAGNOSIS/*EPIDEMIOLOGY
Brain/PATHOLOGY Comparative Study Diagnosis, Differential Hematocrit
Hemoglobins/ANALYSIS Human HIV Infections/*COMPLICATIONS/MORTALITY
Leukocyte Count Nervous System
Diseases/DIAGNOSIS/*EPIDEMIOLOGY/ETIOLOGY Risk Factors Survival
Analysis Toxoplasmosis, Cerebral/DIAGNOSIS/EPIDEMIOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).